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AGI House Newsletter: Big Bets on Healthcare and Talent Shifts in AI
OpenAI’s healthcare push, a Claude research hack, Thinking Machines’ talent exodus, and insights from our AI 4 Healthcare Workshop with Mithrl and Trellis.
AGI House
January 15, 2026 • Estimated Reading Time: 5 minutes
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AI 4 Healthcare
How AI Fundamentally Changing the Healthcare Ecosystem: Insights from Mithrl and Trellis
On Saturday, January 10th, we hosted a technical AI 4 Healthcare workshop at AGI House with Mithrl and Trellis, exploring how AI is pushing biology into a new era of programmability. Mithrl highlighted a critical reality at the frontier: in drug discovery, hallucination isn’t an option. Additionally, an unsolved issue is that scientists often don’t yet know what questions to ask when faced with massive, complex biological datasets.
The hackathon teams built early prototypes directly in this direction: a latent-space drug discovery engine for surfacing novel therapeutics, an AI-powered search layer for public NGS data, and an RNA-seq discovery agent that automatically finds and ranks related experiments. Congratulations to all the winners. We’re excited to keep building around this frontier at AGI House.
Headline
Thinking Machines Lab Loses Key Leaders Back to OpenAI
Two co-founders of Mira Murati’s AI startup Thinking Machines Lab, Barret Zoph and Luke Metz, are departing to rejoin OpenAI alongside another former OpenAI researcher, Sam Schoenholz.
More Headlines
OpenAI is officially going after healthcare. OpenAI has unveiled ChatGPT Health, a dedicated health experience designed to integrate medical records, wearables, and clinical context directly into ChatGPT.
+OpenAI just bought health-records startup Torch to supercharge ChatGPT Health. Torch was working on an app that combined all of a person’s medical information for AI use from a range of sources such as doctor visits, lab tests, wearables, and other portals.
Labs is internal incubator focused on exploring experimental products at the frontier of Claude’s capabilities. The initiative brings on Instagram co-founder and former CPO Mike Krieger to co-lead the Labs team.
Workflow
Anthropic is doubling down on Claude with the launch of Anthropic Labs and it’s easy to see why. Lenny analyzed 320 podcast episodes in under 20 minutes.
Inside a 200,000-Run Experiment on Test-Time Compute
AI21 Labs ran a large-scale 200,000+ SWE-bench Verified campaign and the takeaway is blunt: how you allocate test-time compute matters more than which model you pick. GPT-5 mini, run 8x in parallel with structured orchestration, outperforms single GPT-5 runs at 60% lower cost. In a new technical deep dive, AI21 Labs shows how replacing ReAct loops with explicit plans, automatic horizontal scaling, and decision-theoretic execution reshapes the cost–accuracy trade-off for long-horizon agents. On SWE-bench Verified, orchestrated GPT-5 matches the performance of Claude 4.5 Opus - without changing the model. Full methodology, data, and cost breakdowns included.
Read the full technical blog here: https://www.ai21.com/blog/test-time-compute-swe-bench/
Job Board
We’re Hiring And So Are Our Portfolio Companies
▶ AGI House is building the infrastructure for AGI and is looking for exceptional people to join our core team. We’re hiring a Creative Director to lead creative direction and social at AGI House. Email [email protected]
▶ Develop Health is building AI automation to enable prescribers, with the goal of becoming the agentic clearinghouse in healthcare. Backed by Wing VC and other leading investors. Hiring: AI Engineer, Product Engineer, and Platform & Security Engineer (Bay Area). Email [email protected]
▶ Fergana Labs is a (pro)-consumer AI start-up focused on memory, productivity, and the future of work. Their product, Stash (https://stash.ac), is a do-it-all agent for knowledge work that excels at editing powerpoint slides. Hiring a Founding Engineer. Email [email protected]
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Until next time,
AGI House Team